DSO agent Leon S. Kennedy is on a mission to save Dr. Antonio Taylor from kidnappers, when a mysterious woman thwarts his pursuit. Meanwhile, BSAA agent Chris Redfield investigates a zombie outbreak in San Francisco, where the cause of the infection cannot be identified. The only thing the victims have in common is that they have all recently visited Alcatraz Island. Following this lead, Chris and his team head to the island, where a new horror awaits.