US President Joe Biden tested positive for COVID-19 again on Saturday, just over three days after he was medically cleared to come out of isolation, the White House said, in a rare case of the infection returning after treatment with antivirals.

White House physician Kevin O’Connor said in a letter that Biden “has not experienced a re-emergence of symptoms and continues to feel very well.” O’Connor noted that “there is no reason to restart treatment at this time.”

In accordance with Centers for Disease Control and Prevention ( CDC ) guidelines, Biden will return to isolation for at least five days and remain in the White House until he tests negative. The agency indicated that most of the cases of return of the infection are mild and that no severe symptoms have been reported in that period.

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